Hepatocyte growth factor in cerebrospinal fluid differentiates community-acquired or nosocomial septic meningitis from other causes of pleocytosis
نویسندگان
چکیده
منابع مشابه
Cerebrospinal fluid hepatocyte growth factor level in meningitis.
BACKGROUND AND PURPOSE Hepatocyte growth factor (HGF) is a multifunctional cytokine that has been found to be elevated in tuberculous and bacterial meningitis, but no evaluation has been undertaken of its usefulness in identifying various forms of aseptic meningitis. METHODS In a retrospective study, the levels of HGF in the cerebrospinal fluid of 65 patients were measured prior to treatment....
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Meningitis is one of the most common infectious cerebral nervous system (CNS), defined as an inflammation of the meninges. It is clinically categorized into a chronic and acute based on the acuity of symptoms. Vomiting, bulging fontanel and fever are the main symptoms in the patients with meningitis. Bacterial meningitis is a severe, potentially life-threatening infection that is associated wit...
متن کاملConcentration of soluble form of hepatocyte growth factor receptor in cerebrospinal fluid and serum of patients with bacterial and viral meningitis
Abstract Background and objectives: C-Met is a proto-oncogene that encodes a protein known as hepatocyte growth factor receptor (HGFR). The HGF receptor possesses tyrosine -kinase activity and it is essential for embryonic development, wound healing and cancer. Many proteins are proteolytically released from the surface by a process known as ectodomain shedding. Shedding occurs under normal phy...
متن کاملAssociation between cerebrospinal fluid pleocytosis and enteroviral meningitis.
Mulford et al. (5) recently investigated the correlation between cerebrospinal fluid (CSF) leukocyte count and enteroviral reverse transcription (RT)-PCR results in cases of suspected meningitis. They found that CSF pleocytosis was absent in 30% of infants aged 2 months with a positive enteroviral RT-PCR result, compared with 2% of patients aged 2 months to 18 years and 0% of patients aged 18 y...
متن کاملHepatocyte growth factor levels in cerebrospinal fluid: a comparison between acute bacterial and nonbacterial meningitis.
The organotrophic functions of the hepatocyte growth factor (HGF) have been the subject of several studies. In the more recent studies, this function has been reported in the brain. In the present study, we have measured the levels of HGF in cerebrospinal fluid (CSF) and sera from 78 patients divided into 6 different groups according to central nervous system (CNS) infection and control. Quanti...
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ژورنال
عنوان ژورنال: Fluids and Barriers of the CNS
سال: 2015
ISSN: 2045-8118
DOI: 10.1186/s12987-015-0020-z